2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2417):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178624
    5-Formyl-Dctp
    5-Formyl-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Formyl-Dctp
  • HY-178536
    3'-O-NH2-2'-dA
    3'-O-NH2-2'-dA is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-NH2-2'-dA
  • HY-178598
    (2'OMe-5'p-U)pU
    (2'OMe-5'p-U)pU is a monomeric raw material that can be used for nucleic acid synthesis.
    (2'OMe-5'p-U)pU
  • HY-103400R
    8-Chloroadenosine (Standard)
    8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice.
    8-Chloroadenosine (Standard)
  • HY-171618
    Morpholino U subunit
    Morpholino U subunit is one of the basic units that make up morpholino oligonucleotides. Morpholino U subunit can pair with adenine in the target RNA.
    Morpholino U subunit
  • HY-13605AR
    Cytarabine hydrochloride (Standard)
    Cytarabine (hydrochloride) (Standard) is the analytical standard of Cytarabine (hydrochloride). This product is intended for research and analytical applications. Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
    Cytarabine hydrochloride (Standard)
  • HY-W928636
    5'-O-DMTr-2'-O-4'-C-locked-5-Me-rC(Bz)
    5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-4'-C-locked-5-Me-rC(Bz)
  • HY-178571
    N1-Me-pUMP
    N1-Me-pUMP is a monomeric raw material that can be used for nucleic acid synthesis.
    N1-Me-pUMP
  • HY-171398
    5′-O-Phosphonocytidylyl-(3′→5′)-adenosine
    5′-O-Phosphonocytidylyl-(3′→5′)-adenosine is a diribonucleotide. 5′-O-Phosphonocytidylyl-(3′→5′)-adenosine can be isolated from embryos of the copepod Euchaeta japonica Marukawa.
    5′-O-Phosphonocytidylyl-(3′→5′)-adenosine
  • HY-157504
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
    2’-O-Methyl-5’-O-phosphonoadenylyl-(3’→5’)-guanosine (TEA) is a trinucleotide cap analogue that regulates protein expression in living cells.
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
  • HY-W409644
    N6-Benzoyl-2'-O,4'-C-methyleneadenosine
    N6-Benzoyl-2'-O,4'-C-methyleneadenosine is a monomeric raw material that can be used for nucleic acid synthesis.
    N6-Benzoyl-2'-O,4'-C-methyleneadenosine
  • HY-178675
    (2'OMe-5'p-A)pU
    (2'OMe-5'p-A)pU TEA Salt is a monomeric raw material that can be used for nucleic acid synthesis.
    (2'OMe-5'p-A)pU
  • HY-178577
    CTPαS
    CTPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    CTPαS
  • HY-176025
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate triethylammonium
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate (3'-O-Pivaloyl dATP) triethylammonium is a derivative of 2'-Deoxyadenosine-5'-triphosphate trisodium (HY-136648A).
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate triethylammonium
  • HY-177196
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine is a nucleotide analogue used in nucleic acid synthesis.
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine
  • HY-178623
    DMTr-2'-O-Bn-rG(iBu)-3'-CE-phosphoramidite
    DMTr-2'-O-Bn-rG(iBu)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Bn-rG(iBu)-3'-CE-phosphoramidite
  • HY-178647
    Pyrrolo-dCTP
    Pyrrolo-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.
    Pyrrolo-dCTP
  • HY-W1119955
    Cbz-TRIS-PDA trihydrochloride
    Cbz-TRIS-PDA (trihydrochloride) is a trifunctional compound containing a Cbz protecting group, which can be used in oligonucleotide synthesis.
    Cbz-TRIS-PDA trihydrochloride
  • HY-134382A
    7-CH-dADP trisodium
    7-CH-dADP (7-Deaza-2'-deoxyadenosine-5'-O-diphosphate) trisodium is a dehydroxylated and deaminated derivative of the nucleotide ADP.
    7-CH-dADP trisodium
  • HY-178644
    DMTr-5-Me-dC(C6-O-Lev)-3'-CE-phosphoramidite
    DMTr-5-Me-dC(C6-O-Lev)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-5-Me-dC(C6-O-Lev)-3'-CE-phosphoramidite